Comix Zone is a 1995 arcade-style action game for the Sega Mega Drive/Genesis. The game's most remarkable feature is that it is set within the "panels" of a comic book. Each level consists of two "pages" and secrets are discovered by shredding the "paper" and revealing items. Dialogue is rendered within talk bubbles with the typical comic font. Sprites and backgrounds possess the bright colors and dynamic drawing style favored by superhero comics.

The music was composed by Howard Drossin, a known video game and movie composer. Graphics were done mainly by comic artists.