This Vernacular/Prairie style residence served as home to Mrs. Lucy Kaiser during the last decade of her life. Kaiser, who was born Lucy Whipple in the east, came with her husband, Frank Campbell, in the 1840s to visit her parents who had settled in St. Charles. The Campbells moved further westward to Iowa where they lived on the Mississippi River. Campbell, who installed saw mill machinery, traveled to St. Louis on business and took Lucy along. There she contracted brain fever which left her incapacitated. On recovering, Lucy found out that during her illness her husband had been killed by machinery he had been installing and that her house and mill had been destroyed by a tornado.

Lucy came back to St. Charles to live with her parents following these tragic events. In 1861 she traveled to Washington D.C. to see Lincoln's inauguration. During the Civil War, Kaiser served as a regimental nurse at Jefferson Barracks under General Fremont. For three and a half years she tended to the wounded and dying, taking special care to document the names and addresses of soldiers so that she could contact their relatives. While serving as a regimental nurse, Lucy met A.C. Kaiser, a wounded soldier. The two married in 1864 after she received her honorable discharge.

Lucy left St. Charles after the death of her second husband in 1908. Although she was eligible to be buried in Arlington National Cemetery, Lucy requested burial in St. Charles. She was buried in North Cemetery in 1915.